GROWTH-HORMONE AND SOMATOMEDIN BEHAVIOR IN NEWBORN

被引：35

作者：

GIORDANO, G ^{[1
]}

FOPPIANI, E ^{[1
]}

MINUTO, F ^{[1
]}

PERRONI, D ^{[1
]}

机构：

[1] UNIV GENOA, IST SCI MED INTERN, CATTEDRA ENDOCRINOL & PATOL COSTITUZIONALE, GENOA, ITALY

来源：

ACTA ENDOCRINOLOGICA | 1976年 / 81卷 / 03期

关键词：

D O I：

10.1530/acta.0.0810449

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human growth hormone (HGH) and somatomedin (Sm) concentrations were studied in a group of newborns. Plasma HGH values were 41.17 .+-. 24.26 (SD) ng/ml (14.00-90.00 ng/ml) and the Sm value was 0.59 .+-. 0.43 (SD) U/ml (0.18-1.8 U/ml); the difference between these values and the ones observed in normal adults (2.45 .+-. 2.53 (SD) ng/ml and 1.16 .+-. 0.28 (SD) U/ml respectively) were statistically significant. While GH values were higher than in normal adult controls, somatomedin was significantly decreased. The dissociation between human GH and somatomedin in the newborn may reflect a reduced biosynthesis of the somatomedin-generating system and consequently a lack of feedback control on GH exerted by somatomedin.

引用

页码：449 / 454

页数：6

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