REVERSE-PHASE HPLC ANALYSIS OF THE ANTIVIRAL DRUG, 9-[1,3-DIHYDROXY-2-PROPOXY METHYL]-GUANINE (DHPG), WITH AMPEROMETRIC DETECTION

被引：6

作者：

VISOR, GC

JACKSON, SE

KENLEY, RA

LEE, G

机构：

[1] Syntex Research, Inst of, Pharmaceutical Sciences, Palo Alto,, CA, USA, Syntex Research, Inst of Pharmaceutical Sciences, Palo Alto, CA, USA

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1985年 / 8卷 / 08期

关键词：

ELECTROCHEMISTRY;

D O I：

10.1080/01483918508067158

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This report describes a reverse-phase chromatographic method with amperometric detection and an electroactive internal standard (tyrosine) for analyzing 9- left bracket 1,3-dihydroxy-2-propoxy)methyl right bracket guanine (DHPG) in a parenteral dosage form. Statistical validation of the method showed good recovery efficiency and reproducibility. Parallel analysis of partially degraded DHPG solution samples by LCEC and by a cation-exchange chromatographic system with 254-m detection demonstrated statistically equivalent estimations of the DHPG degradation rate constant.

引用

页码：1475 / 1488

页数：14

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