PHYSICAL-CHEMISTRY OF ACTIN - PAST, PRESENT AND FUTURE

被引：28

作者：

OOSAWA, F

机构：

[1] Aichi Institute of Technology, Toyota

来源：

BIOPHYSICAL CHEMISTRY | 1993年 / 47卷 / 02期

关键词：

ACTIN; G-F TRANSFORMATION; MUSCLE DYNAMICS; SLIDING MACHINE; LOOSE COUPLING;

D O I：

10.1016/0301-4622(93)85028-G

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

History of actin research is reviewed with special emphasis on dynamics of the G-F transformation and flexibility or intrafilamentous mobility of F-actin. Good correlation was found between the flexibility of F-actin and its activity in cell motility. In molecular machines such as the flagellar motor and the sliding machine of F-actin and myosin, the coupling between influx and efflux seems to be loose. F-actin would assume multiple active states during sliding on myosin with hydrolysis of ATP. Recently, the three-dimensional structure of actin molecule in crystals has been determined. Actin research is expected to give an answer to the question on the physiological significance of internal mobility of protein molecules and their assemblies and the structural origin of such mobility.

引用

页码：101 / 111

页数：11

共 56 条

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[2]

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