POTENTIOMETRIC DETERMINATION OF THE PARTITION AND DISTRIBUTION COEFFICIENTS OF DIANIONIC COMPOUNDS

被引：6

作者：

CLARKE, FH ^{[1
]}

CAHOON, NM ^{[1
]}

机构：

[1] ROBERTSON MICROLIT LABS INC,MADISON,NJ 07940

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1995年 / 84卷 / 01期

关键词：

D O I：

10.1002/jps.2600840113

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The potentiometric determination of the partition and distribution coefficients of two dianionic hexapeptide derivatives is described. For each of these compounds, the partition coefficient of the dianion makes the largest contribution to the distribution coefficient at pH 7.4.

引用

页码：53 / 54

页数：2

共 6 条

[1] PH-METRIC LOG-P .1. DIFFERENCE PLOTS FOR DETERMINING ION-PAIR OCTANOL-WATER PARTITION-COEFFICIENTS OF MULTIPROTIC SUBSTANCES [J].