DIFFERENTIAL PATTERNS OF LAMININ EXPRESSION IN LATERAL AND MEDIAL MIDBRAIN GLIA

被引：30

作者：

GARCIAABREU, J

CAVALCANTE, LA

NETO, VM

机构：

[1] UNIV FED RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,PROGRAMA NEUROBIOL,BR-21949900 RIO JANEIRO,BRAZIL

[2] UNIV FED RIO DE JANEIRO,ICB,DEPT HISTOL & EMBRIOL,BR-21949900 RIO JANEIRO,BRAZIL

来源：

NEUROREPORT | 1995年 / 6卷 / 05期

关键词：

ASTROCYTES; ASTROGLIA; EXTRACELLULAR MATRIX; MIDBRAIN; MOUSE;

D O I：

10.1097/00001756-199503270-00014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AN analysis of the extra cellular matrix (ECM) in regionally heterogeneous midbrain glia has been started. Immunoreactivity to laminin has been tested in confluent glial cultures from lateral (L) and medial (M) sectors of 14 days mouse embryos (E14) and in neurone-glia cocultures kept for 48 hours after plating of E14 midbrain freshly-dissociated neurones. Laminin is present in both types of glial cultures, but its distribution assumes a punctate pattern in glia that is not permissive for neurite growth (M-glia) and a fibrillar configuration in a favourable glial substrate (L-glia). Moreover, laminin expression is dramatically upregulated in co-cultures although fibrillar and punctate patterns are maintained.

引用

页码：761 / 764

页数：4

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