ALTERNATIVE SUBSTRATE AND INHIBITION-KINETICS OF AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE-2''-I IN SUPPORT OF A THEORELL-CHANCE KINETIC MECHANISM

被引：15

作者：

GATES, CA ^{[1
]}

NORTHROP, DB ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH PHARM,DIV PHARMACEUT BIOCHEM,MADISON,WI 53706

来源：

BIOCHEMISTRY | 1988年 / 27卷 / 10期

关键词：

D O I：

10.1021/bi00410a046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：3826 / 3833

页数：8

共 33 条

[1]

BARMAN TE, 1969, ENZYME HDB, V1, P491

[2] PARTITION ANALYSIS AND CONCEPT OF NET RATE CONSTANTS AS TOOLS IN ENZYME-KINETICS [J].

CLELAND, WW .

BIOCHEMISTRY, 1975, 14 (14) :3220-3224

[3]

CLELAND WW, 1963, BIOCHIM BIOPHYS ACTA, V67, P188

[4] REGRESSION-ANALYSIS OF NONLINEAR ARRHENIUS PLOTS - AN EMPIRICAL-MODEL AND A COMPUTER-PROGRAM [J].

DUGGLEBY, RG .

COMPUTERS IN BIOLOGY AND MEDICINE, 1984, 14 (04) :447-455

[5] KINETIC DISTINCTION OF ORDERED AND RANDOM BI-REACTANT ENZYME-SYSTEMS [J].

FRIEDEN, C .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1976, 68 (03) :914-917

[6]

GATES CA, 1985, FED PROC, V44, P1810

[7] SUBSTRATE SPECIFICITIES AND STRUCTURE ACTIVITY RELATIONSHIPS FOR THE NUCLEOTIDYLATION OF ANTIBIOTICS CATALYZED BY AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE-2''-I [J].

GATES, CA ;

NORTHROP, DB .

BIOCHEMISTRY, 1988, 27 (10) :3820-3825

[8] KINETIC DISTINCTION BETWEEN RAPID-EQUILIBRIUM RANDOM AND ABORTIVE ORDERED ENZYMATIC MECHANISMS USING ALTERNATIVE SUBSTRATES OR KINETIC ISOTOPE EFFECTS [J].

GATES, CA ;

NORTHROP, DB .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 152 (01) :406-410

[9] DETERMINATION OF THE RATE-LIMITING SEGMENT OF AMINOGLYCOSIDE NUCLEOTIDYLTRANSFERASE-2''-I BY PH-DEPENDENT AND VISCOSITY-DEPENDENT KINETICS [J].

GATES, CA ;

NORTHROP, DB .

BIOCHEMISTRY, 1988, 27 (10) :3834-3842

[10]

GATES CA, 1984, FED P FED AM SOC EXP, V43, P1874

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