ANTIGENIC DETERMINANT(S) SHARED BY THE HUMAN THY-1 AND HUMAN-IGG

被引：9

作者：

BONEWALD, L

WANG, AC

WANG, IY

BALCH, CM

ADES, EW

机构：

[1] MED UNIV S CAROLINA, DEPT BIOCHEM, CHARLESTON, SC 29425 USA

[2] UNIV ALABAMA, BIRMINGHAM, AL 35294 USA

[3] ELI LILLY & CO, LILLY RES LAB, INDIANAPOLIS, IN 46285 USA

来源：

IMMUNOBIOLOGY | 1984年 / 166卷 / 4-5期

关键词：

D O I：

10.1016/S0171-2985(84)80020-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A human T cell differentiation antigen (p25) previously described as being the mouse theta equivalent was examined for shared antigenic determinants with Ig. A strong cross-reactivity of an antiserum prepared against p25 antigen was established with human IgG subclasses. This antiserum does not react with human IgM or IgA, nor with primate Ig. The shared determinants appear to be associated with the disulfide-bonded cysteines in the 1st and 3rd constant domains of the IgG molecule and the 9-112 disulfide bond of Thy 1.

引用

页码：428 / 438

页数：11

共 26 条

[1] ISOLATION AND PARTIAL CHARACTERIZATION OF THE HUMAN HOMOLOG OF THY-1 [J].