TCDD RESISTANCE IS INHERITED AS AN AUTOSOMAL DOMINANT TRAIT IN THE RAT

被引：20

作者：

POHJANVIRTA, R

机构：

[1] Department of Environmental Hygiene and Toxicology, National Public Health Institute, Kuopio

来源：

TOXICOLOGY LETTERS | 1990年 / 50卷 / 01期

关键词：

2; 3; 7; 8-Tetrachlorodibenzo-P-dioxin; Inheritance of sensitivity; Rat strains; TCDD;

D O I：

10.1016/0378-4274(90)90251-G

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In the present study, genetic crossings were performed between the most TCDD-susceptible (Long-Evans) and the most TCDD-resistant (Han/Wistar) rat strains. The F1 offspring were as resistant to TCDD as the Han/Wistar rats irrespective of the sex of their Han/Wistar parents. In test-cross and F2 progeny the distribution of resistant and susceptible phenotypes was consistent with inheritance regulated by 2 (possibly 3) autosomal genes displaying complete dominance, independent segregation, and an additive co-effect. These data show that, in contrast to earlier findings in mice, TCDD resistance seems to be the dominant trait in the rat. Moreover, the results challenge the current view that the Ah-locus is the exclusive determinant of TCDD sensitivity. © 1990.

引用

页码：49 / 56

页数：8

共 32 条

[1]

[Anonymous], 1956, NONPARAMETRIC STAT B

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