CHARACTERIZATION OF A TISSUE KALLIKREIN IN HUMAN PROLACTIN-SECRETING ADENOMAS

被引：39

作者：

JONES, TH

FIGUEROA, CD

SMITH, C

CULLEN, DR

BHOOLA, KD

机构：

[1] UNIV SHEFFIELD,NO GEN HOSP,DEPT MED,HERRIES RD,SHEFFIELD S5 7AU,ENGLAND

[2] UNIV BRISTOL,SCH MED,DEPT PHARMACOL,BRISTOL BS8 1TD,AVON,ENGLAND

[3] ROYAL HALLAMSHIRE HOSP,DEPT NEUROPATHOL & MED,SHEFFIELD S10 2JF,S YORKSHIRE,ENGLAND

来源：

JOURNAL OF ENDOCRINOLOGY | 1990年 / 124卷 / 02期

关键词：

D O I：

10.1677/joe.0.1240327

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunoreactive tissue kallikrein was co-localized with prolactin in all the eleven prolactin-secreting adenomas of the human anterior pituitary gland examined in this study. The intracellular distribution of immunoreactivity in the prolactin-secreting cells suggests that tissue kallikrein is located within the Golgi complex of these cells. Both the intracellular hormone-processing action and the kininogenase activity of tissue kallikrein may be of functional importance in human prolactinomas.

引用

页码：327 / &

共 27 条

[1] DEVELOPMENT AND CHARACTERIZATION OF A RADIOIMMUNOASSAY TO MEASURE HUMAN-TISSUE KALLIKREIN IN BIOLOGICAL-FLUIDS [J].