HIGH-SPEED MEMORY SCANNING IN PARKINSONS-DISEASE - ADVERSE-EFFECTS OF LEVODOPA

被引：82

作者：

POEWE, W ^{[1
]}

BERGER, W ^{[1
]}

BENKE, T ^{[1
]}

SCHELOSKY, L ^{[1
]}

机构：

[1] UNIV HOSP NEUROL INNSBRUCK,INNSBRUCK,AUSTRIA

来源：

ANNALS OF NEUROLOGY | 1991年 / 29卷 / 06期

关键词：

D O I：

10.1002/ana.410290616

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

High-speed memory scanning as assessed by the Sternberg paradigm was studied in 12 nondemented patients with fluctuating Parkinson's disease and 13 age-matched healthy controls. Patients were first assessed before taking their morning dose of levodopa ("off") and again after that dose had produced full clinical effect ("on"). Although motor components of the measured choice reaction time were slower in patients when off than in control subjects, memory scanning speed was not different. After levodopa (on), patients' motor time normalized, but cognitive processing speed became significantly slower when compared with previous performance in the off condition and with controls. Contrary to previous concepts of bradyphrenia in patients with Parkinson's disease, these results indicate that dopaminergic stimulation can reduce cognitive processing speed.

引用

页码：670 / 673

页数：4

共 23 条

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