EFFECTS OF ANTIBIOTICS AND OTHER DRUGS ON TOXIN PRODUCTION IN CLOSTRIDIUM-DIFFICILE INVITRO AND INVIVO

被引：18

作者：

BARC, MC

DEPITRE, C

CORTHIER, G

COLLIGNON, A

SU, WJ

BOURLIOUX, P

机构：

[1] CTR ETUD PHARMACEUT, FAC PHARM, MICROBIOL LAB, F-92296 CHATENAY MALABRY, FRANCE

[2] INRA, ECOL & PHYSIOL SYST DIGEST LAB, F-78352 JOUY EN JOSAS, FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 06期

关键词：

D O I：

10.1128/AAC.36.6.1332

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In an attempt to understand more completely why patients treated with phenothiazines (chlorpromazine and cyamemazine), methotrexate, and certain antibiotics such as clindamycin have an increased risk of developing pseudomembranous colitis, the production of toxins A and B by Clostridium difficile in the presence of these drugs was measured in vitro as well as in vivo by using axenic mice. None of the drugs tested increased the production of toxins either in vitro or in vivo.

引用

页码：1332 / 1335

页数：4

共 32 条

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