GLUCOSE-TURNOVER IN TYPE-1 DIABETIC SUBJECTS DURING EXERCISE - EFFECT OF SELECTIVE AND NONSELECTIVE BETA-BLOCKADE AND INSULIN WITHDRAWAL

OBJECTIVE - To assess the effect of selective beta1-blockade (atenolol and betaxolol) and nonselective beta-blockade (propranolol) on glucose turnover in subjects with insulin-dependent (type I) diabetes mellitus during moderate exercise. RESEARCH DESIGN AND METHODS- Five subjects with type I diabetes were infused with insulin and then exercised for 1 h, after pretreatment with each of the three drugs or saline and, on a separate day, after withdrawal of insulin. Glucose turnover was measured using tritiated glucose. RESULTS - Plasma glucose, initially 9.2 +/- 0.5 mmol/L (mean +/- SE) when insulin infused and 14.0 +/- 0.8 when insulin was withdrawn, fell on exercise by 3.4 +/- 1.1 mmol/L (P < 0.05) saline, 4.0 +/- 0.8 mmol/L (P < 0.01) with betaxolol, 3.8 +/- 0.7 mmol/L (P < 0.01) with atenolol, 5.0 +/- 0.6 mmol/L (P < 0.005) with propranolol, and 1. 7 +/- 1.0 mmol/L (NS) when insulin was withdrawn. Propranolol, but not the other beta-blockers, caused a significantly greater fall in glucose on exercise than during the control study. Glucose appearance rate (R(a)) was similar basally and rose to an almost identical level in all five groups during exercise. Glucose disappearance rate (R(d)) rose similarly during exercise, except after propranolol when the rise was significantly greater than with saline (P < 0.01). Failure of glucose to change significantly during exercise when insulin had been withdrawn was associated with the smallest rise in R(d) and the highest nonesterified fatty acid concentrations. Propranolol and betaxolol, but not atenolol, reduced nonesterified fatty acids. CONCLUSIONS- We conclude that the greater fall in glucose on exercise after beta-blocking drugs is probably largely a direct effect of beta2-blockade on muscle, increasing the exercise-induced rise in R(d) glucose. This offers support to the use of beta1-specific drugs, where beta-blockade is necessary in type I diabetes.