HIGH-LEVELS OF SPONTANEOUS DRUG-RESISTANCE IN LACTOBACILLUS

被引：65

作者：

CURRAGH, HJ ^{[1
]}

COLLINS, MA ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,CTR AGR & FOOD SCI,DEPT FOOD MICROBIOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

JOURNAL OF APPLIED BACTERIOLOGY | 1992年 / 73卷 / 01期

关键词：

D O I：

10.1111/j.1365-2672.1992.tb04965.x

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A range of lactobacilli was screened to find the naturally occurring levels of drug resistance. During the screening process two cultures exhibited variation in their sensitivity to nitrofurazone. Further examination showed that for a number of lactobacilli, nitrofurazone-resistant cells arose at a high spontaneous frequency (10(-4)-10(-5)). The frequency/rate of mutation to resistance was investigated for a further five antibiotics, the results suggesting that high spontaneous mutation frequencies are not uncommon.

引用

页码：31 / 36

页数：6

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