STEREOCONTROLLED CATALYTIC ASYMMETRIC REDUCTION OF KETONES WITH OXAZABOROLIDINES DERIVED FROM NEW CHIRAL AMINO-ALCOHOLS

被引：53

作者：

KIM, YH ^{[1
]}

PARK, DH ^{[1
]}

BYUN, IS ^{[1
]}

YOON, IK ^{[1
]}

PARK, CS ^{[1
]}

机构：

[1] KOREA RES INST CHEM TECHNOL,TAEJON 305606,SOUTH KOREA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 17期

关键词：

D O I：

10.1021/jo00069a002

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The highly stereocontrolled enantioselective reduction of ketones in the presence of catalytic amounts of new chiral (S)-beta-amino alcohols 1 and 2 with borane in THF at -78-degrees-C proceeds in high chemical and optical yields; secondary alcohols with the R-configuration are obtained in the presence of 1b, but secondary alcohols with the S-configuration are obtained in the presence of 2a.

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收藏

页码：4511 / 4512

页数：2

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