PERICYTE MODULATION OF TUBULAR FORMATION AND CYTOSKELETAL ACTIN DISTRIBUTION IN PULMONARY MICROVESSEL ENDOTHELIAL-CELLS

被引：6

作者：

MOREL, NML ^{[1
]}

HECHTMAN, HB ^{[1
]}

SHEPRO, D ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT SURG,CAMBRIDGE,MA 02138

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1993年 / 3卷 / 02期

关键词：

ACTIN; ENDOTHELIAL CELLS; INTERENDOTHELIAL JUNCTIONS; PERICYTE; PERMEABILITY; TGF-BETA;

D O I：

10.1159/000154675

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lung pericytes (PC) have been isolated and identified by several criteria: morphology, immunology, and contractile response. Evidence is presented that pulmonary PC in coculture affect endothelial cell (EC) differentiation by stimulating tube formation and by promoting a dense peripheral band of actin that in tum promotes close apposition of EC. These cellular changes appear to be regulated in part by low levels (0.01 ng/ml) of transforming growth factor beta.

引用

收藏

页码：127 / 136

页数：10

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