ISCHEMIA - REPERFUSION INJURY

被引：569

作者：

GRACE, PA

机构：

[1] Department of Surgery, Royal Postgraduate Medical School, Hammersmith Hospital, London

来源：

BRITISH JOURNAL OF SURGERY | 1994年 / 81卷 / 05期

关键词：

D O I：

10.1002/bjs.1800810504

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Ischaemia-reperfusion injury is a complex phenomenon often encountered in surgical practice. The consequences of such injury are local and remote tissue destruction, and sometimes death. Several different processes have been implicated. This review discusses the pathology of such injury, the mechanisms of free radical production, and the role of neutrophils and endothelial factors in ischaemia-reperfusion. Finally, several mechanisms that limit ischaemia-reperfusion injury are discussed and a number of novel therapies presented.

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页码：637 / 647

页数：11

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