CORNEAL SMALL-ANGLE LIGHT-SCATTERING THEORY - WAVY FIBRIL MODELS

Small-angle light-scattering (SALS) measurements of the cornea together with electron micrographs of the corneal stroma suggest that the waviness in the stromal collagen fibrils of corneas fixed at zero pressure is the structural feature responsible for the cross-polarized SALS patterns. This paper derives and discusses a Born approximation to the parallel- and cross-polarized SALS patterns expected from lamellae of long, thin, optically anisotropic wavy fibrils whose axes are parallel to each other and are spatially distributed about one another in a quasi-ordered fashion. The patterns predicted for anisotropic fibrils with a random distribution of lamella orientations or with distributions of lamella orientations that have one or two preferred directions superimposed upon a random background agree with the qualitative features of the experimental patterns observed with rabbit corneas. Experimental evidence in support of the distributions with preferred orientations is discussed. 34 refs.