IMMUNOGENICITY OF SALMONELLA-TYPHI TY21A VACCINE FOR YOUNG-CHILDREN

被引:38
作者
MURPHY, JR
GREZ, L
SCHLESINGER, L
FERRECCIO, C
BAQAR, S
MUNOZ, C
WASSERMAN, SS
LOSONSKY, G
OLSON, JG
LEVINE, MM
机构
[1] CATHOLIC UNIV CHILE, CTR DIAGNOST, SANTIAGO, CHILE
[2] UNIV CHILE, INST NUTR & FOOD TECHNOL, IMMUNOL LAB, SANTIAGO, CHILE
[3] MINIST SALUD, TYPHOID FEVER CONTROL PROGRAM, SANTIAGO, CHILE
[4] UNIV MARYLAND, SCH MED, DEPT PEDIAT, DIV INFECT DIS & TROP PEDIAT, BALTIMORE, MD 21201 USA
[5] USN, MED RES UNIT 3, CAIRO, EGYPT
[6] UNIV TEXAS, HLTH SCI CTR, SCH PUBL HLTH, CTR INFECT DIS, HOUSTON, TX 77225 USA
关键词
D O I
10.1128/IAI.59.11.4291-4293.1991
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An attenuated Salmonella typhi Ty21a vaccine was administered to 18 infants and toddlers (less-than-or-equal-to 24 months old) to determine its safety and immunogenicity. The vaccination (10(9) CFU per dose, three doses) was well tolerated. However, after the vaccination there was no evidence of a humoral or cellular immune response to S. typhi. The vaccine used was known to be immunogenic for older children and adults. The results support the view that the immunogenicity of Ty21a is age dependent.
引用
收藏
页码:4291 / 4293
页数:3
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