CLONING AND SEQUENCE OF REV7, A GENE WHOSE FUNCTION IS REQUIRED FOR DNA DAMAGE-INDUCED MUTAGENESIS IN SACCHAROMYCES-CEREVISIAE

被引：31

作者：

TORPEY, LE ^{[1
]}

GIBBS, PEM ^{[1
]}

NELSON, J ^{[1
]}

LAWRENCE, CW ^{[1
]}

机构：

[1] UNIV ROCHESTER, SCH MED & DENT, DEPT BIOPHYS, ROCHESTER, NY 14642 USA

来源：

YEAST | 1994年 / 10卷 / 11期

关键词：

REV7; SACCHAROMYCES CEREVISIAE; INDUCED MUTAGENESIS;

D O I：

10.1002/yea.320101115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of the REV7 gene is required for DNA damage-induced mutagenesis in budding yeast, Saccharomyces cerevisiae, and is therefore thought to promote replication past sites of mutagen damage in the DNA template. We have cloned this gene by complementation of the rev7-2 mutant defect, and determined its sequence. REV7 encodes a predicted protein of M(r) 28 759 which is unlike any other protein in the NCBI non-redundant protein sequence data base, and which is inessential for viability. The sequence of the 3.88 kb yeast genomic fragment containing REM has been deposited in Genbank accession number U07228.

引用

页码：1503 / 1509

页数：7

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