EPITHELIAL ANTIBIOTICS INDUCED AT SITES OF INFLAMMATION

被引：356

作者：

SCHONWETTER, BS

STOLZENBERG, ED

ZASLOFF, MA

机构：

[1] Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462

来源：

SCIENCE | 1995年 / 267卷 / 5204期

关键词：

D O I：

10.1126/science.7886453

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of antimicrobial peptides in epithelial defense is not fully understood. An epithelial beta-defensin, lingual antimicrobial peptide (LAP), was isolated from bovine tongue and the corresponding complementary DNA cloned. LAP showed a broad spectrum of antibacterial and antifungal activities. LAP messenger RNA abundance was markedly increased in the epithelium surrounding naturally occurring tongue lesions. This increase coincided with the cellular hallmarks of acute and chronic inflammation in the underlying lamina propria, supporting a role for epithelial antimicrobial peptides as integral components of the inflammatory response.

引用

页码：1645 / 1648

页数：4

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