MYCOBACTERIUM AND LEISHMANIA - STOWAWAYS IN THE ENDOSOMAL NETWORK

被引：68

作者：

RUSSELL, DG

机构：

[1] David Russell is at the Dept of Molecular Microbiology, Washington University Medical School, St Louis

来源：

TRENDS IN CELL BIOLOGY | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/S0962-8924(00)88963-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microbial pathogens have evolved to exploit a wide range of niches inside the vertebrate host cell. Both Leishmania and Mycobacterium species remain within vacuoles following phagocytosis by their host's macrophages. Leishmania survives in acidic, lysosomal compartments, whereas Mycobacterium species limit the maturation of their phagosomes into hydrolytic lysosomes. Recent advances in our appreciation of the biology of these pathogens is providing unique insights into the normal conversion of phagosomes into lysosomes.

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页码：125 / 128

页数：4

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