PROTECTION AGAINST MICROCYSTIN-LR-INDUCED HEPATOTOXICITY BY SILYMARIN - BIOCHEMISTRY, HISTOPATHOLOGY, AND LETHALITY

被引：96

作者：

MEREISH, KA

BUNNER, DL

RAGLAND, DR

CREASIA, DA

机构：

[1] USA,MED RES INST INFECT DIS,DIV PATHOL,FREDERICK,MD 21702

[2] USA,MED RES INST INFECT DIS,DIV PATHOPHYSIOL,FREDERICK,MD 21702

来源：

PHARMACEUTICAL RESEARCH | 1991年 / 8卷 / 02期

关键词：

ALANINE AMINOTRANSFERASE; FLAVONOID; HEPATIC NECROSIS; HEPATOTOXIN; LACTATE DEHYDROGENASE; MICROCYSTIN-LR; SILYMARIN; SORBITOL DEHYDROGENASE;

D O I：

10.1023/A:1015868809990

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

Microcystin-LR, a cyclic heptapeptide synthesized by the blue-green algae, Microcystis aeruginosa, is a potent hepatotoxin. Pathological examination of livers from mice and rats that reveived microcystin-LR revealed severe, peracute, diffuse, centrilobular hepatocellular necrosis, and hemorrhage. These changes were correlated with increased serum activities of sorbitol dehydrogenase, alanine aminotransferase, and lactate dehydrogenase. Pretreatment of either rats or mice with a single dose of silymarin, a flavonolignane isolated from the wild artichoke (Silybum marianum L. Gaertn), completely abolished the lethal effects, pathological changes, and significantly decreased the levels of serum enzymes induced by microcystin-LR intoxication.

引用

页码：273 / 277

页数：5

共 21 条

[1]

PATHOPHYSIOLOGIC EFFECTS OF A TOXIC PEPTIDE FROM MICROCYSTIS-AERUGINOSA [J].