SYNTHESIS AND CALCIUM-ANTAGONIST ACTIVITY OF DIALKYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(NITROGENOUS HETEROARYL)-3,5-PYRIDINE DICARBOXYLATES

被引：15

作者：

BARALDI, PG

BUDRIESI, R

CACCIARI, B

CHIARINI, A

GARUTI, L

GIOVANNINETTI, G

LEONI, A

ROBERTI, M

机构：

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 1992年 / 57卷 / 01期

关键词：

D O I：

10.1135/cccc19920169

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of 4-(nitrogenous heteroaryl)-1,4-dihydropyridine antagonists II-XVI were synthesized and screened for inotropic, chronotropic and calcium antagonist properties, in order to evaluate the effect on pharmacological activity of replacement of the 4-aryl group of nifedipine-like drugs by heterocyclic moieties, such as quinoline, indole, carbazole and pyrazole. The most potent bradycardic compounds of the series (VIII-X, XII and XIII) elicited weak calcium antagonist activity and were stronger negative inotropic.

引用

页码：169 / 178

页数：10

共 16 条

[1]

Baraldi P.G., 1989, DRUG DES DELIVERY, V5, P13

[2] POTENTIAL ANTITUBERCULOSIS AGENTS OF THE INDOLE SERIES [J].

DOYLE, FP ;

FERRIER, W ;

HOLLAND, DO ;

MEHTA, MD ;

NAYLER, JHC .

JOURNAL OF THE CHEMICAL SOCIETY, 1956, (AUG) :2853-2857

[3]

GARUTI L, 1987, PHARMAZIE, V42, P378

[4]

Garuti L, 1989, Boll Chim Farm, V128, P136

[5]

HOF RP, 1987, AM J CARDIOL, V59, P308

[6]

Janis RA, 1987, ADV DRUG RES, V16, P309

[7] Syntheses in the quinoline series. II. Some derivatives of 4-methylquinoline and a study of their structures [J].

Johnson, OH ;

Hamilton, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1941, 63 :2864-2867

[8]

Kendall H E, 1987, Prog Med Chem, V24, P249, DOI 10.1016/S0079-6468(08)70424-7

[9]

LEIR CM, 1986, Patent No. 4565872

[10]

PH BHN, 1951, J ORG CHEM, V16, P1327

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