ROLE OF ENDOTHELIN AND PLATELET-ACTIVATING-FACTOR IN INDOMETHACIN-INDUCED GASTRIC-MUCOSAL INJURY IN RATS

被引：19

作者：

KITAJIMA, T ^{[1
]}

YAMAGUCHI, T ^{[1
]}

TANI, K ^{[1
]}

KUBOTA, Y ^{[1
]}

OKUHIRA, M ^{[1
]}

INOUE, K ^{[1
]}

YAMADA, H ^{[1
]}

机构：

[1] SHIGA UNIV MED SCI,DEPT ANAT 2,OTSU,SHIGA 52021,JAPAN

来源：

DIGESTION | 1993年 / 54卷 / 03期

关键词：

INDOMETHACIN; GASTRIC LESION; ENDOTHELIN; PLATELET-ACTIVATING FACTOR;

D O I：

10.1159/000201030

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The current study was designed to investigate the role of two potent vasoactive substances, endothelin (ET) and platelet-activating factor (PAF), in the pathogenesis of indomethacin-induced gastric lesions in rats. Treatment with anti-ET antibody before indomethacin administration resulted in a significant decline in the total length of the lesions as determined by gross evaluation. In contrast, CV-6209, a specific PAF antagonist, had no effect on the total length of the lesions. The results strongly suggest the incorporation of endogenous ET in the mechanism of gastric damage after indomethacin administration.

引用

页码：156 / 159

页数：4

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