LACK OF A DETECTABLE EFFECT OF CAPSID PROTEINS ON THE CELL-DEPENDENT ACTIVITY OF PARVOVIRUS MVMP PROMOTERS

Deletion of upstream elements from the early P4 promoter of parvovirus MVM (minute virus of mice, prototype strain MVMp) has a differential effect on its activity, depending on the host cell considered. This indicates that upstream motifs participate in the control of promoter P4 functioning and are responsive to factors which are, at least in part, cell-type specific. In contrast with other viral systems, the capsid proteins of MVMp had no detectable effect on gene expression driven by either the early P4 or late P38 promoter of MVMp in permissive and non-permissive cells.