PARTICLE BEAM INTERFACE FOR LIQUID-CHROMATOGRAPHY MASS-SPECTROMETRY

被引：23

作者：

LIGON, WV

DORN, SB

机构：

[1] General Electric Company, Corporate Research and Development, Schenectady

来源：

ANALYTICAL CHEMISTRY | 1990年 / 62卷 / 23期

关键词：

D O I：

10.1021/ac00222a011

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A modified particle-beam-type liquid chromatography/mass spectrometry interface has been developed that is designed to be fully compatible with the vacuum requirements of a high-resolution double focusing mass spectrometer. important features include a three-stage momentum separator, a nebulizer that is both ultrasonic and pneumatic, and an in-chamber desolvation heater. The momentum separator provides ion source pressures of (2–3) × 10−6 Torr for most solvents. The nebulizer is capable of handling high liquid chromatography flow rates while being much less sensitive to dispersion gas flow rate than Is a purely pneumatic nebulizer. The in-chamber desolvatlon heater is feedback controlled by downstream gas temperature in order to automatically compensate for changes in solvent encountered during gradient elutlons. © 1990, American Chemical Society. All rights reserved.

引用

页码：2573 / 2580

页数：8

共 8 条

[1]

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[2]

Brandt R., 1989, U. S. Patent, Patent No. [4,863,491, 4863491]

[3]

BROWNER RF, 1986, Patent No. 4629478

[4]

SAUTER AD, 1987, MAR P PITTSB C EXP A