BIOSENSORS - TRENDS AND COMMERCIALIZATION

被引:87
作者
SCHELLER, FW
SCHUBERT, F
RENNEBERG, R
MULLER, HG
JANCHEN, M
WEISE, H
机构
[1] RES INST MED DIAGNOST,DRESDEN 80,GER DEM REP
[2] INST TECH MICROBIOL,DDR-1117 BERLIN,GER DEM REP
关键词
BIOMEDICAL EQUIPMENT - Electrodes - ELECTROCHEMISTRY - Applications - ENZYMES - Chemical Reactions - OPTOELECTRONIC DEVICES - Applications - TRANSDUCERS - Design;
D O I
10.1016/0265-928X(85)80001-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Biosensors are based on the direct coupling of a matrix-bound bioactive substance, which is responsible for the specific recognition of the species of interest, and a physico-chemical transducer supplying an electric output signal which is processed by the electronic component. The aim of this combination is the specific and sensitive determination of a large spectrum of substances in clinical laboratories, fermentation processes and pollution control. Biosensors for about 100 different parameters have been described in the literature; however, biosensor-based analyzers have been commercialized for only 11 substances. Their functional characteristics are presented here. The following main aspects are discussed: integration of the biosensor components; designing and application of coupled enzyme reactions; immunosensors and microbial electrodes; and electrochemical modulation of the recognition process.
引用
收藏
页码:135 / 160
页数:26
相关论文
共 50 条