THE PRESENCE OF FREE D-SERINE, D-ALANINE AND D-PROLINE IN HUMAN PLASMA

被引：119

作者：

NAGATA, Y

MASUI, R

AKINO, T

机构：

[1] OSAKA UNIV, FAC SCI, DEPT BIOL, OSAKA, JAPAN

[2] SAPPORO MED COLL, DEPT BIOCHEM, SAPPORO, HOKKAIDO 060, JAPAN

来源：

EXPERIENTIA | 1992年 / 48卷 / 10期

关键词：

D-ALANINE; D-PROLINE; D-SERINE; GLOMERULONEPHRITIS; PLASMA;

D O I：

10.1007/BF01919147

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Twelve neutral free amino acids, i.e. serine, threonine, glutamine, asparagine, alanine, proline, methionine, tyrosine, valine, leucine, isoleucine and phenylalanine, were surveyed for the presence of D-enantiomers in plasma samples from patients with renal diseases and from normal subjects. D-serine, D-alanine and D-proline were found in the patient's plasma. The highest concentrations (D/L ratio) of D-serine, D-alanine and D-proline were 0.2362, 0.2087 and 0.0986, respectively. The sum of the contents of the three D-amino acids in a plasma sample correlated with the serum creatinine level of the subject. No D-amino acid was shown to be present in the plasma proteins.

引用

页码：986 / 988

页数：3

共 14 条

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