RAPID INCREASES IN CEREBELLAR PURKINJE-CELL GLUTAMIC-ACID DECARBOXYLASE (GAD(67)) MESSENGER-RNA AFTER LESION-INDUCED INCREASES IN CELL FIRING

被引：18

作者：

DRENGLER, SM ^{[1
]}

OLTMANS, GA ^{[1
]}

机构：

[1] UNIV HLTH SCI CHICAGO MED SCH,DEPT PHARMACOL & MOLEC BIOL,N CHICAGO,IL 60064

来源：

BRAIN RESEARCH | 1993年 / 615卷 / 01期

关键词：

GLUTAMIC ACID DECARBOXYLASE; PURKINJE CELL; FIRING RATE; CLIMBING FIBER LESION; CEREBELLUM; GLUTAMIC ACID DECARBOXYLASE(67) MESSENGER RNA; MESSENGER RNA STABILITY;

D O I：

10.1016/0006-8993(93)91129-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Loss of the inferior olive-climbing fiber input to the cerebellar cortex doubles the simple spike activity of the cerebellar Purkinje cell. There is a 3- to 4-fold increase in Purkinje cell messenger RNA for the 67 kDa form of glutamic acid decarboxylase (a synthetic enzyme for the neurotransmitter GABA) within 4-5 h of the increase in electrical activity, suggesting a rapid response of mechanisms influencing neurotransmitter synthesis or stability to altered electrophysiological activity.

引用

页码：175 / 179

页数：5

共 32 条

[1] CENTRAL NEUROTOXIC EFFECTS OF INTRAPERITONEALLY ADMINISTERED 3-ACETYLPYRIDINE, HARMALINE AND NIACINAMIDE IN SPRAGUE-DAWLEY AND LONG-EVANS RATS - A CRITICAL-REVIEW OF CENTRAL 3-ACETYLPYRIDINE NEUROTOXICITY [J].

BALABAN, CD .

BRAIN RESEARCH REVIEWS, 1985, 9 (01) :21-42

[2]

BATINI C, 1985, EXP BRAIN RES, V59, P404

[3]

BENEDETTI F, 1984, EXP BRAIN RES, V55, P368

[4] INFERIOR OLIVE INACTIVATION DECREASES THE EXCITABILITY OF THE INTRACEREBELLAR AND LATERAL VESTIBULAR NUCLEI IN THE RAT [J].

BENEDETTI, F ;

MONTAROLO, PG ;

STRATA, P ;

TEMPIA, F .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 340 (JUL) :195-208

[5] PREGANGLIONIC NERVE-STIMULATION INCREASES MESSENGER-RNA LEVELS FOR TYROSINE-HYDROXYLASE IN THE RAT SUPERIOR CERVICAL-GANGLION [J].

BIGUET, NF ;

RITTENHOUSE, AR ;

MALLET, J ;

ZIGMOND, RE .

NEUROSCIENCE LETTERS, 1989, 104 (1-2) :189-194

[6] 2 HUMAN GLUTAMATE DECARBOXYLASES, 65-KDA GAD AND 67-KDA GAD, ARE EACH ENCODED BY A SINGLE GENE [J].

BU, DF ;

ERLANDER, MG ;

HITZ, BC ;

TILLAKARATNE, NJK ;

KAUFMAN, DL ;

WAGNERMCPHERSON, CB ;

EVANS, GA ;

TOBIN, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (06) :2115-2119

[7] COMPARATIVE DISTRIBUTION OF MESSENGER-RNAS FOR GLUTAMIC-ACID DECARBOXYLASE, TYROSINE-HYDROXYLASE, AND TACHYKININS IN THE BASAL GANGLIA - AN INSITU HYBRIDIZATION STUDY IN THE RODENT BRAIN [J].

CHESSELET, MF ;

WEISS, L ;

WUENSCHELL, C ;

TOBIN, AJ ;

AFFOLTER, HU .

JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 262 (01) :125-140

[8] OLIVOCEREBELLAR SYSTEM .1. DELAYED AND SLOW INHIBITORY EFFECTS - OVERLOOKED SALIENT FEATURE OF CEREBELLAR CLIMBING FIBERS [J].

COLIN, F ;

MANIL, J ;

DESCLIN, JC .

BRAIN RESEARCH, 1980, 187 (01) :3-27

[9] EFFECTS OF 3-ACETYLPYRIDINE ON CENTRAL NERVOUS-SYSTEM OF RAT, AS DEMONSTRATED BY SILVER METHODS [J].

DESCLIN, JC ;

ESCUBI, J .

BRAIN RESEARCH, 1974, 77 (03) :349-364

[10] 2 GENES ENCODE DISTINCT GLUTAMATE DECARBOXYLASES [J].

ERLANDER, MG ;

TILLAKARATNE, NJK ;

FELDBLUM, S ;

PATEL, N ;

TOBIN, AJ .

NEURON, 1991, 7 (01) :91-100

← 1 2 3 4 →