DIRECT CHIRAL ACHIRAL HPLC SEPARATION OF ISOMERS OF ANTIEMETIC QUINUCLIDINES

被引：1

作者：

MCKEAN, R ^{[1
]}

KUMAR, N ^{[1
]}

QUINTY, R ^{[1
]}

机构：

[1] RHONE POULENC RORER CENT RES,DEPT ANALYT & PHYS CHEM,500 ARCOLA RD,POB 1200,COLLEGEVILLE,PA 19426

来源：

JOURNAL OF CHROMATOGRAPHIC SCIENCE | 1993年 / 31卷 / 11期

关键词：

D O I：

10.1093/chromsci/31.11.465

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Separation of a multicomponent mixture of positional isomers, diastereomers, and enantiomers of the antiemetic quinuclidine (RG 12915) in one chromatographic run is described. This is achieved by chiral-achiral chromatography in the normal-phase mode. Chiralcel OD is used for direct chiral separation and is coupled to a short silica column for achiral selectivity. The method uses column switching and only one mobile phase composition throughout the analysis.© 1993 Oxford University Press. © Oxford University Press 1993.

引用

页码：465 / 468

页数：4

共 9 条

[1]

FITZPATRICK LR, 1990, J PHARMACOL EXP THER, V254, P450

[2]

Ohnishi A., 1989, U.S. Patent, Patent No. 4

[3] OPTICAL RESOLUTION OF RACEMIC DRUGS BY CHIRAL HPLC ON CELLULOSE AND AMYLOSE TRIS(PHENYLCARBAMATE) DERIVATIVES [J].