DOES HIGH MHC CLASS-II GENE-EXPRESSION IN NORMAL LUNGS ACCOUNT FOR THE STRONG IMMUNOGENICITY OF LUNG ALLOGRAFTS

被引：3

作者：

ALWAYN, IPJ

XU, RK

ADLER, WH

KITTUR, DS

机构：

[1] Leiden University Medical School, Leiden, NL-2333 AA

[2] Division of Transplant Surgery, The Johns Hopkins Medical Institutions, Baltimore, 21287, MD, Harvey 805

[3] Gerontology Research Center, NIA, Baltimore, 21287, MD

来源：

TRANSPLANT INTERNATIONAL | 1994年 / 7卷 / 01期

关键词：

LUNG TRANSPLANTATION; MICE; MHC CLASS II EXPRESSION; LUNG; REJECTION;

D O I：

10.1007/BF00335663

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Clinical experience has demonstrated that lung allografts are considerably more immunogenic than liver allografts although both organs contain equivalent amounts of lymphoreticular tissue. Northern blot analysis of MHC class II gene expression in various murine organs with I-AB and I-EB gene-specific oligonucleotide probes revealed that MHC class II expression in lungs is semiquantitatively higher than in the liver and other organs with the exception of the spleen. We conclude that this high MHC class II expression strongly suggests that the lymphoreticular tissue in the lungs is in a state of activation. This may be an important reason for the strong immunogenicity of lung allografts.

引用

页码：43 / 46

页数：4

共 18 条

[1]

Burke C.M., Glanville A.R., Theodore J., Robin E.D., Lung immunogenicity, rejection, and obliterative bronchiolitis, Chest, 92, pp. 547-549, (1987)

[2]

Calne R.Y., Sells R.A., Pena J.R., Davis D.R., Millard P.R., Herbertson B.M., Binns R.M., Davies D.A., Induction of immunological tolerance by porcine liver allografts, Nature, 223, pp. 472-476, (1969)

[3]

Chang S.C., Hsu H.K., Perng R.P., Shiao G.M., Lin C.Y., Increased expression of MHC class II antigens in rejecting canine lung allografts, Transplantation, 49, pp. 1158-1163, (1990)

[4]

Chirgwin J.M., Przybyla A.E., MacDonald R.J., Rutter W.J., Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, 18, (1979)

[5]

Daar A.S., Fuggle S.V., Fabre J.W., Ting A., Morris P.J., The detailed distribution of MHC class II antigens in normal human organs, Transplantation, 38, (1984)

[6]

Egan T.M., Kaiser L.R., Cooper J.D., Lung transplantation (review), Curr Probl Surg, 26, pp. 673-751, (1989)

[7]

Hruban R.H., Beschorner W.E., Baumgartner W.A., Marsh B.R., Traill T.A., Achuff S.C., Ren H., Reitz B.A., Hutchins G.M., Evidence that the expression of class II MHC antigens is not diagnostic of lung allograft rejection, Transplantation, 48, pp. 529-530, (1989)

[8]

Mason D.W., Dallman M., Barclay A.N., Graft-versus-host disease induces expression of Ia antigen in rat epidermal cells and gut epithelium, Nature, 293, (1981)

[9]

Pober J.S., Collins T., Gimbrone M.A., Libby P., Reiss C.S., Inducible expression of class II Major histocompatibility complex antigens and the immunogenicity of vascular endothelium, Transplantation, 41, pp. 141-146, (1986)

[10]

Prop J., Nieuwenhuis P., Wildevuur C.R.H., Lung allograft rejection in the rat. I. Accelerated rejection caused by graft lymphocytes, Transplantation, 40, (1985)

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