HEPATOPROTECTIVE ACTIVITY OF CARROT (DAUCUS-CAROTA L) AGAINST CARBON-TETRACHLORIDE INTOXICATION IN MOUSE-LIVER

被引：98

作者：

BISHAYEE, A ^{[1
]}

SARKAR, A ^{[1
]}

CHATTERJEE, M ^{[1
]}

机构：

[1] JADAVPUR UNIV, DEPT PHARMACEUT TECHNOL, DIV BIOCHEM, CALCUTTA 700032, W BENGAL, INDIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 47卷 / 02期

关键词：

CARBON TETRACHLORIDE; HEPATIC DAMAGE; SERUM AND LIVER ENZYMES; CARROT EXTRACT; HEPATOPROTECTION;

D O I：

10.1016/0378-8741(95)01254-B

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effect of carrot extract on carbon tetrachloride (CCl4)-induced acute liver damage was evaluated. The increased serum enzyme levels (viz., glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate dehydrogenase, alkaline phosphatase, sorbitol and glutamate dehydrogenase) by CCl4-induction were significantly lowered due to pretreatment with the extract. The extract also decreased the elevated serum bilirubin and urea content due to CCl4 administration. Increased activities of hepatic 5'-nucleotidase, acid phosphatase, acid ribonuclease and decreased levels of succinic dehydrogenase, glucose-6-phosphatase and cytochrome P-450 produced by CCl4 were reversed by the extract in a dose-responsive way. Results of this study revealed that carrot could afford a significant protective action in the alleviation of CCl4-induced hepatocellular injury.

引用

页码：69 / 74

页数：6

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