MULTIDRUG-RESISTANCE IN PEDIATRIC MALIGNANCIES

被引：39

作者：

CHAN, HSL

DEBOER, G

HADDAD, G

GALLIE, BL

LING, V

机构：

[1] UNIV TORONTO,TORONTO,ON,CANADA

[2] TORONTO SUNNYBROOK REG CANC CTR,TORONTO,ON,CANADA

[3] ONTARIO CANC INST,TORONTO,ON M4X 1K9,CANADA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1995年 / 9卷 / 02期

关键词：

D O I：

10.1016/S0889-8588(18)30096-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Many sensitive immunohistochemical and molecular biologic tools have been developed to detect the multidrug resistance P-glycoprotein in tumor samples. In this article, the suitability of these tools for clinical use is assessed and evidence for the relevance of P-glycoprotein in mediating resistance to chemotherapy for treatment of childhood malignancies is evaluated. Preliminary results from some of the current studies suggest that pharmacologic modulation of normally effective chemotherapy might overcome some therapeutic failures owing to overexpression of P-glycoprotein in certain malignancies with lower levels of multidrug resistance.

引用

页码：275 / 318

页数：44

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