DIASTEREOSELECTIVE IODOCARBOCYCLIZATION OF 4-PENTENYLMALONATE DERIVATIVES - APPLICATION TO CYCLOSARKOMYCIN SYNTHESIS

被引：30

作者：

KITAGAWA, O ^{[1
]}

INOUE, T ^{[1
]}

TAGUCHI, T ^{[1
]}

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)79965-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The iodocarbocyclization of 4-pentenylmalonate I having a substituent at the 2 or 3 position effectively proceeded by treating I with I-2 and Ti(OtBu)(4) in the presence of CuO. Stereoelectronic effect of the subtituent at allylic position on diastereoselectivity was notable. As an application of the present reaction, the efficient synthesis of cyclosarkomycin 7 was achieved.

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页码：1059 / 1062

页数：4

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