GENETIC FUSIONS THAT HELP DEFINE A TRANSCRIPTION TERMINATION REGION IN ESCHERICHIA-COLI

被引：13

作者：

MITCHELL, DH ^{[1
]}

REZNIKOFF, WS ^{[1
]}

BECKWITH, J ^{[1
]}

机构：

[1] HARVARD UNIV, MED SCH, DEPT MICROBIOL & MOLEC GENET, BOSTON, MA 02115 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1976年 / 101卷 / 04期

关键词：

D O I：

10.1016/0022-2836(76)90239-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The trpA gene product was analyzed from a class of strains of E. coli K12 in which the lac operon was fused by deletion to the trp operon. These are strains that retained the ability to synthesize tryptophan. Two of these strains make a wild-type trpA product; these strains retain intact all structural genes of the trp operon. The lac operon in these strains is apparently fused to a region of the trp operon between trpA, the last gene in the operon, and the region where trp mRNA synthesis terminates. The region where trp mRNA synthesis terminates thus is distinct from the trp structural genes.

引用

页码：441 / 457

页数：17

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