SYNTHESIS AND BIOLOGICAL EVALUATION OF 8-DEAZAHOMOFOLIC ACID AND ITS TETRAHYDRO DERIVATIVE

被引：6

作者：

DEGRAW, JI

COLWELL, WT

BROWN, VH

SATO, M

KISLIUK, RL

GAUMONT, Y

THORNDIKE, J

SIROTNAK, FM

机构：

[1] TUFTS UNIV,SCH MED,DEPT BIOCHEM,BOSTON,MA 02111

[2] SLOAN KETTERING CANC CTR,DEPT MOLEC THERAPEUT,NEW YORK,NY 10021

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1988年 / 31卷 / 01期

关键词：

D O I：

10.1021/jm00396a022

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：150 / 153

页数：4

共 11 条

[1]

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[2]

DEGRAW J, 1976, J HETEROCYCL CHEM, V13, P349

[3] SYNTHESIS OF HOMOFOLIC ACID [J].

DEGRAW, JI ;

MARSH, JP ;

ACTON, EM ;

CREWS, OP ;

MOSHER, CW ;

FUJIWARA.AN ;

GOODMAN, L .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (10) :3404-&

[4] ANTIMICROBIAL ACTIVITY OF 8-DEAZAFOLIC ACID [J].

DEGRAW, JI ;

KISLIUK, RL ;

GAUMONT, Y ;

BAUGH, CM .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (04) :470-471

[5]

DEGRAW JI, 1979, CHEM BIOL PTERIDINES, P229

[6] TETRAHYDROHOMOFOLATE SPECIFIC INHIBITOR OF THYMIDYLATE SYNTHETASE [J].

GOODMAN, L ;

KISLIUK, RL ;

FRIEDKIN, M ;

MORNINGSTAR, JF ;

KWOK, G ;

PASTORE, EJ ;

RATZAN, J ;

CRAWFORD, EJ ;

ALNAHAS, A ;

DONOVAN, EF ;

WILSON, L ;

PLANTE, LT ;

DEGRAW, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (02) :308-&

[7]

HAKALA MT, 1971, CANCER RES, V31, P813

[8]

KISLIUK RL, 1971, ANN NY ACAD SCI, V186, P438, DOI 10.1111/j.1749-6632.1971.tb46998.x

[9]

KISLIUK RL, 1982, NEW APPROACHES DESIG, P201

[10]

MEAD JAR, 1966, CANCER RES, V26, P2374

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