ACIDIC FIBROBLAST GROWTH-FACTOR DELAYS INVITRO ISCHEMIA-INDUCED INTRACELLULAR CALCIUM ELEVATION IN GERBIL HIPPOCAMPAL SLICES - A SIGN OF NEUROPROTECTION

被引：24

作者：

MITANI, A

OOMURA, Y

YANASE, H

KATAOKA, K

机构：

[1] EHIME UNIV,SCH MED,DEPT PHYSIOL,SHIGENOBU,EHIME 79102,JAPAN

[2] NIPPON ZOKI PHARMACEUT CO LTD,INST BIOACT SCI,YASHIRO,HYOGO 67314,JAPAN

[3] TOYAMA MED & PHARMACEUT UNIV,INST WAKANYAKU,SUGITANI,TOYAMA 93001,JAPAN

来源：

NEUROCHEMISTRY INTERNATIONAL | 1992年 / 21卷 / 03期

关键词：

D O I：

10.1016/0197-0186(92)90184-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using microfluorometry, effects of acidic fibroblast growth factor (aFGF) on the in vitro ischemia-induced intracellular calcium elevation were investigated in gerbil hippocampal slices at 35-degrees-C. When slices were superfused with hypoxic and glucose-free medium, the mean latency of the in vitro ischemia-induced calcium elevation was 209 +/- 51 s. The addition of aFGF in medium (25 mug/l) delayed the calcium elevation throughout the experiments: the mean latency was 541 +/- 94 s. This retardation in calcium elevation may be indicative of neuroprotective nature of aFGF.

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页码：337 / 341

页数：5

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