19-NOR-DEOXYCORTICOSTERONE EXCRETION IN RATS BRED FOR SUSCEPTIBILITY AND RESISTANCE TO THE HYPERTENSIVE EFFECTS OF SALT

被引：15

作者：

DALE, SL

HOLBROOK, MM

MELBY, JC

机构：

[1] BOSTON UNIV, MED CTR,EVANS MEM DEPT CLIN RES, ENDOCRINOL & METAB SECT,75 E NEWTON ST, BOSTON, MA 02118 USA

[2] BOSTON UNIV HOSP, MED CTR, DEPT MED, BOSTON, MA 02218 USA

来源：

ENDOCRINOLOGY | 1985年 / 117卷 / 06期

关键词：

D O I：

10.1210/endo-117-6-2424

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rats susceptible (S/JR) and resistant (R/JR) to the hypertensive effect of salt were weaned at 28 days of age and placed on a high salt intake. Blood pressure, measured at 4-5 and 8-9 weeks of age (after 5 weeks of high salt intake), demonstrated a slight increase in R/JR rats and a highly significant increase in S/JR rats. Urinary free 19-nor-deoxycorticosterone (19-nor-DOC) levels measured in weekly urine collections were found to be markedly elevated in S/JR rats compared to levels in R/JR rats. Since 19-nor-DOC has been shown to be a potent mineralocorticoid, the results suggest that elevated production of 19-nor-DOC may have a role in hypertension in rats susceptible to the hypertensive effects of salt.

引用

收藏

页码：2424 / 2427

页数：4

相关论文

共 20 条

[1] BIOASSAY OF MINERALOCORTICOIDS - RELATIONSHIP OF STRUCTURE TO PHYSIOLOGICAL ACTIVITY [J].

AXELRAD, BJ ;

CATES, JE ;

JOHNSON, BB ;

LUETSCHER, JA .

ENDOCRINOLOGY, 1954, 55 (05) :568-574

[2] ROLE OF GENETIC FACTORS IN SUSCEPTIBILITY TO EXPERIMENTAL HYPERTENSION DUE TO CHRONIC EXCESS SALT INGESTION [J].

DAHL, LK ;

HEINE, M ;

TASSINARI, L .

NATURE, 1962, 194 (4827) :480-&

[3] EFFECTS OF CHRONIC EXCESS SALT INGESTION - EVIDENCE THAT GENETIC FACTORS PLAY AN IMPORTANT ROLE IN SUSCEPTIBILITY TO EXPERIMENTAL HYPERTENSION [J].

DAHL, LK ;

HEINE, M ;

TASSINARI, L .

JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (06) :1173-&

[4] 19-NOR-DEOXYCORTICOSTERONE METABOLISM BY RAT ADRENAL-GLANDS - EVIDENCE FOR THE FORMATION OF 19-NOR-CORTICOSTERONE AND 19-NOR-18-HYDROXYDEOXYCORTICOSTERONE [J].

DALE, SL ;

HOLBROOK, MM ;

ARISON, BH ;

MELBY, JC .

ENDOCRINOLOGY, 1985, 116 (01) :118-123

[5] 19-NOR-DEOXYCORTICOSTERONE IN THE NEUTRAL FRACTION OF HUMAN-URINE [J].

DALE, SL ;

HOLBROOK, MM ;

MELBY, JC .

STEROIDS, 1981, 37 (01) :103-109

[6] URINARY 19-NOR-DEOXYCORTICOSTERONE EXCRETION IN THE SPONTANEOUSLY HYPERTENSIVE RAT [J].

DALE, SL ;

HOLBROOK, MM ;

KOMANICKY, P ;

MELBY, JC .

ENDOCRINOLOGY, 1982, 110 (06) :1989-1993

[7] 19-NOR-DEOXYCORTICOSTERONE - POTENT MINERALOCORTICOID ISOLATED FROM THE URINE OF RATS WITH REGENERATING ADRENALS [J].

GOMEZSANCHEZ, CE ;

HOLLAND, OB ;

MURRY, BA ;

LLOYD, HA ;

MILEWICH, L .

ENDOCRINOLOGY, 1979, 105 (03) :708-711

[8] URINARY FREE AND SERUM 19-NOR-DEOXYCORTICOSTERONE IN ADRENAL REGENERATION HYPERTENSION [J].

GOMEZSANCHEZ, CE ;

GOMEZSANCHEZ, EP ;

UPCAVAGE, RJ ;

HALL, EB .

HYPERTENSION, 1983, 5 (02) :I32-I34

[9] TRANSITORY INCREMENT IN URINARY FREE 19-NOR-DEOXYCORTICOSTERONE AFTER DIURETIC-INDUCED RENIN STIMULATION [J].

GRIFFING, GT ;

WILSON, TE ;

MELBY, JC .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1984, 59 (05) :931-935

[10]

KAGAWA CM, 1957, P SOC EXP BIOL MED, V94, P444