RECOMBINANT HUMAN INSULIN-LIKE GROWTH-FACTOR-I DECREASES SERUM LIPOPROTEIN(A) CONCENTRATIONS IN NORMAL ADULT MEN

被引:45
作者
OSCARSSON, J
LUNDSTAM, U
GUSTAFSSON, B
WILTON, P
EDEN, S
WIKLUND, O
机构
[1] GOTHENBURG UNIV, DEPT PHYSIOL, S-41390 GOTHENBURG, SWEDEN
[2] GOTHENBURG UNIV, DEPT HEART & LUNG DIS, S-41390 GOTHENBURG, SWEDEN
[3] PHARMACIA AB, DEPT BIOCHEM & CLIN RES, STOCKHOLM, SWEDEN
[4] PHARMACIA AB, DEPT PEPTIDE HORMONES, STOCKHOLM, SWEDEN
关键词
D O I
10.1111/j.1365-2265.1995.tb02699.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE Lipoprotein(a) is a lipoprotein fraction associated with atherosclerosis. The serum concentration of lipoprotein(a) has been shown to be mainly genetically determined but recently evidence for hormonal regulation has been presented. The aim of the present study was to investigate the effects of insulin-like growth factor-I on serum lipoproteins, especially lipoprotein(a). DESIGN The effects of one week of IGF-I treatment were studied in an open trial. SUBJECTS Ten healthy men, who participated in a pharmacokinetic study, were given recombinant human insulin-like growth factor-I (40 mu g/kg/day) as daily subcutaneous injections. MEASUREMENTS Serum samples for measurements of lipoproteins were taken after an overnight fast before and after 7 days of treatment. RESULTS There was a decrease in serum lipoprotein(a) concentration (18.5 +/- 5.5%) in nine of the subjects, and a slight increase in one of the subjects with the lowest concentrations. Also serum; apolipoprotein (b) (6.3 +/- 2.2%), serum cholesterol (10.6 +/- 1.8%) and serum triglyceride (14.8 +/- 4.8%) concentrations decreased. An unexpected finding was that fasting serum glucose concentrations increased (13 +/- 4%). CONCLUSION Insulin-like growth factor-I is involved in the regulation of lipoprotein(a) concentrations, which might have novel therapeutic implications.
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页码:673 / 676
页数:4
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