EFFECT OF PROGESTERONE ON NOREPINEPHRINE RELEASE FROM MOUSE ADRENERGIC TERMINALS INVITRO

被引:8
作者
PADILLA, L [1 ]
ASENCIO, H [1 ]
FERNANDEZ, W [1 ]
CRUZ, MA [1 ]
NEUMANN, V [1 ]
REINICKE, K [1 ]
RUDOLPH, MI [1 ]
机构
[1] UNIV CONCEPCION, FAC CIENCIAS BIOL & RECURSOS NAT, DEPT CIENCIAS FISOL, CASILLA 2407, CONCEPCION, CHILE
来源
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM | 1991年 / 22卷 / 04期
关键词
D O I
10.1016/0306-3623(91)90071-D
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The in vitro effect of progesterone on norepinephrine (NE) release and contractile activity was analyzed in uterine horns from estrogen-primed and progesterone-primed mice. 2. Progesterone (6-10 nmol/ml) evoked the release of [H-3]NE above basal levels from uterine horns in both experimental conditions, the effect of progesterone on estrogen-primed being more important than on progesterone-primed mice uterus. 3. Progesterone also increased electrically evoked [H-3]NE release in estrogen-primed uterine tissue, nevertheless no effect was observed in progesterone-primed ones. 4. Progesterone (0.6-10 nmol/ml) inhibited uterine horn isometric contractions only in estradiol-primed mice. This effect was partially blocked in uterine horns from reserpine-treated mice and when propanolol (1-mu-M) was added to the preparation of estradiol-primed mice uterus.
引用
收藏
页码:647 / 650
页数:4
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