A NOVEL SYNTHESIS OF NUCLEOSIDE 5'-TRIPHOSPHATES

被引：38

作者：

MISHRA, NC ^{[1
]}

BROOM, AD ^{[1
]}

机构：

[1] UNIV UTAH,COLL PHARM,DEPT MED CHEM,308 SKAGGS HALL,SALT LAKE CITY,UT 84112

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 18期

关键词：

D O I：

10.1039/c39910001276

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Facile syntheses of ribonucleoside 5'-triphosphates have been accomplished in good yield (> 60%) in a one-pot reaction of unprotected nucleosides with phosphoryl chloride followed by treatment of the resulting phosphorodichloridate with tri-n-butylammonium phosphate in the presence of dimethylformamide.

引用

页码：1276 / 1277

页数：2

共 22 条

[1] POLYRIBONUCLEOTIDES CONTAINING THIOPURINES - SYNTHESIS AND PROPERTIES OF POLY(1-METHYL-6-THIOGUANYLIC ACID) [J].

AMARNATH, V ;

BROOM, AD .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 479 (01) :16-23

[2] POLYRIBONUCLEOTIDES - THE ROLE OF ACID-BASE PROPERTIES IN HYDROGEN-BOND INTERACTIONS [J].

AMARNATH, V ;

BROOM, AD .

NUCLEOSIDES & NUCLEOTIDES, 1982, 1 (02) :163-171

[3] NEW DATA ON THE CONFORMATION OF NUCLEOSIDE 5'-DI-TRIPHOSPHATES AND 5'-TRIPHOSPHATES OBTAINED BY ROESY EXPERIMENTS [J].

ANDRE, F ;

DEMASSIER, V ;

BLOCH, G ;

NEUMANN, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (19) :6784-6789

[4] COMBINED ENZYMATIC AND CHEMICAL APPROACHES TO SYNTHESIS OF UNIQUE POLYRIBONUCLEOTIDES [J].

BROOM, AD ;

UCHIC, ME ;

UCHIC, JT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 425 (03) :278-286

[5]

FURUSAWA K, 1976, J CHEM SOC P1, P11

[6] DERIVATIVES OF GUANOSINE TRIPHOSPHATE WITH RIBOSE 2'-HYDROXYL SUBSTITUENTS - INTERACTIONS WITH PROTEIN SYNTHETIC ENZYMES OF ESCHERICHIA-COLI [J].

HAMEL, E .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1976, 70 (02) :339-347

[7] CONVERSION OF MONO- AND OLIGODEOXYRIBONUCLEOTIDES TO 5'-TRIPHOSPHATES [J].

HOARD, DE ;

OTT, DG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (08) :1785-&

[8] P-31 NUCLEAR MAGNETIC-RESONANCE SPECTRA OF THIOPHOSPHATE ANALOGS OF ADENINE-NUCLEOTIDES - EFFECTS OF PH AND MG2+ BINDING [J].

JAFFE, EK ;

COHN, M .

BIOCHEMISTRY, 1978, 17 (04) :652-657

[9] SIMPLE SYNTHESIS OF 5-VINYL- AND 5-ETHYNYL-2'-DEOXYURIDINE-5'-TRIPHOSPHATES [J].

KOVACS, T ;

OTVOS, L .

TETRAHEDRON LETTERS, 1988, 29 (36) :4525-4528

[10] RIBONUCLEOSIDE PHOSPHATES VIA PHOSPHORIMIDAZOLIDATE INTERMEDIATES - SYNTHESIS OF PSEUDOADENOSINE 5'-TRIPHOSPHATE [J].

KOZARICH, JW ;

CHINAULT, AC ;

HECHT, SM .

BIOCHEMISTRY, 1973, 12 (22) :4458-4463

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