EFFECTS OF CHRONIC FOOD RESTRICTION ON PRODYNORPHIN-DERIVED PEPTIDES IN RAT-BRAIN REGIONS

被引:38
作者
BERMAN, Y
DEVI, L
CARR, KD
机构
[1] NYU,MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10016
[2] NYU,MED CTR,DEPT PHARMACOL,NEW YORK,NY 10016
关键词
DYNORPHIN; FOOD RESTRICTION; REWARD;
D O I
10.1016/0006-8993(94)91952-6
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chronic food restriction produces a variety of physiological and behavioral adaptations including a potentiation of the reinforcing effect of food, drugs and lateral hypothalamic electrical stimulation. Previous work in this laboratory has revealed that the lowering of self-stimulation threshold by food restriction is reduced by mu- and kappa-selective opioid antagonists. In the present study, the effect of chronic food restriction on levels of three prodynorphin-derived peptides, namely dynorphin A(1-17) (A(1-17)), dynorphin A(1-8) A(1-8) and dynorphin B-1-13 (B-1-13) were measured in eleven brain regions known to be involved in appetite, taste and reward. Food restriction increased levels of A(1-17) in dorsal medial (+19.6%), ventral medial (+24.2%) and medial preoptic (+82.9%) hypothalamic areas. Levels of A(1-17) decreased in the central nucleus of the amygdala (-35.1%). Food restriction increased levels of A(1-8) in nucleus accumbens (+34.4%), bed nucleus of the stria terminalis (+24.5%) and lateral hypothalamus (+41.9%). Food restriction had no effect on levels of B-1-13. A(1-17) is highly kappa-preferring and the brain regions in which levels increased all have a high ratio of kappa:mu and delta receptors. A(1-8) is less discriminating among opioid receptor types and the brain regions in which levels increased have a low ratio of kappa:mu and delta receptors. The present results suggest that food restriction alters posttranslational processing within the dynorphin A domain of the prodynorphin precursor, possibly leading to a change in the balance between kappa and non-kappa opioid receptor stimulation in specific brain regions.
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收藏
页码:49 / 53
页数:5
相关论文
共 41 条
[1]  
ADLER MW, 1986, HOMEOSTASIS THERMAL, P160
[2]  
[Anonymous], 1993, OPIOIDS, DOI 10.1007/978-3-642-77460-7_26
[3]  
BERMAN Y, IN PRESS BIOCHIMIE
[4]   MODULATION OF TASTE AFFECT BY HUNGER, CALORIC SATIETY, AND SENSORY-SPECIFIC SATIETY IN THE RAT [J].
BERRIDGE, KC .
APPETITE, 1991, 16 (02) :103-120
[5]   RELATIVE EFFECTS OF NUTRITIONAL DEFICIT AND DEPRIVATION PERIOD ON RATE OF ELECTRICAL SELF-STIMULATION OF LATERAL HYPOTHALAMUS [J].
BLUNDELL, JE ;
HERBERG, LJ .
NATURE, 1968, 219 (5154) :627-&
[6]   PHYSIOLOGICAL ROLE OF PLEASURE [J].
CABANAC, M .
SCIENCE, 1971, 173 (4002) :1103-+
[7]   DIFFERENTIAL EFFECTS OF AMPHETAMINE AND FOOD-DEPRIVATION ON SELF-STIMULATION OF LATERAL HYPOTHALAMUS AND MEDIAL FRONTAL CORTEX [J].
CAREY, RJ ;
GOODALL, E ;
LORENS, SA .
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1975, 88 (01) :224-230
[8]   ANTIBODIES TO DYNORPHIN-A(1-13) BUT NOT BETA-ENDORPHIN INHIBIT ELECTRICALLY ELICITED FEEDING IN THE RAT [J].
CARR, KD ;
BAK, TH ;
GIOANNINI, TL ;
SIMON, EJ .
BRAIN RESEARCH, 1987, 422 (02) :384-388
[9]   EFFECTS OF ANTIBODIES TO DYNORPHIN-A AND BETA-ENDORPHIN ON LATERAL HYPOTHALAMIC SELF-STIMULATION IN AD-LIBITUM FED AND FOOD-DEPRIVED RATS [J].
CARR, KD .
BRAIN RESEARCH, 1990, 534 (1-2) :8-14
[10]   ROSTRAL AND CAUDAL VENTRICULAR INFUSION OF ANTIBODIES TO DYNORPHIN A(1-17) AND DYNORPHIN A(1-8) - EFFECTS ON ELECTRICALLY-ELICITED FEEDING IN THE RAT [J].
CARR, KD ;
BAK, TH .
BRAIN RESEARCH, 1990, 507 (02) :289-294