THE EFFECT OF HCG SUPPLEMENTATION AFTER COMBINED GNRH AGONIST HMG TREATMENT IN AN IVF PROGRAM

被引:43
作者
BELAISCHALLART, J
DEMOUZON, J
LAPOUSTERLE, C
MAYER, M
机构
[1] Department of Obstetrics and Gynaecology, Hôpital A. Béclère
[2] Unité, INSERM 292, Hôpital Kremlin Bicêtre
[3] Laboratoires Organon, 93204 Saint Denis
关键词
HCG; IVF; LHRH agonists; Luteal-phase supplementation;
D O I
10.1093/oxfordjournals.humrep.a137062
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The necessity of luteal-phase supplementation in an IVF programme is of continuing interest. After ovarian stimulation with clomiphene and human menopausal gonadotrophin (HMG), the beneficial effect of supporting the luteal phase has never been scientifically demonstrated. After ovarian stimulation with GnRH agonist/HMG, the luteal phase seems to be inadequate, but in a previous study we did not find evidence to support the need for oral progesterone supplementation. To evaluate the beneficial effect of human chorionic gonadotrophin (HCG) supplementation, we performed a multicentre, double-blind, randomized study with HCG (193 transfers) against placebo (194 transfers). The ongoing pregnancy rate per transfer cycle was significantly better with HCG (18.7 versus 9.3). This is the first truly objective (randomized) study demonstrating the beneficial effect of supporting the luteal phase in an IVF programme. © 1990 Oxford University Press.
引用
收藏
页码:163 / 166
页数:4
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