DIPHENYLHYDANTOIN ATTENUATES HYPOXIA-INDUCED RELEASE OF [H-3] GLUTAMATE FROM RAT HIPPOCAMPAL SLICES

被引：18

作者：

POTTER, PE

DETWILER, P

THORNE, B

MOSKAL, JR

机构：

[1] MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT NEUROSURG,BRONX,NY 10467

[2] CHICAGO INST NEUROSURG & NEURORES,CHICAGO,IL 60614

来源：

BRAIN RESEARCH | 1991年 / 558卷 / 01期

关键词：

DIPHENYLHYDANTOIN; GLUTAMATE; HIPPOCAMPUS; HYPOXIA; ISCHEMIA; PHENYTOIN; STROKE;

D O I：

10.1016/0006-8993(91)90728-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The ability of diphenylhydantoin (DPH) to prevent hypoxia-induced [H-3]glutamate release was examined in perfused rat hippocampal slices. Hypoxia (25 min; 95% N2/5% CO2) caused a prolonged release of [H-3]glutamate, which was reduced significantly if DPH (20-mu-M) was present from the beginning of the perfusion. Perfusion with oxygenated medium (reoxygenation) following hypoxia also caused a pronounced release of glutamate. A therapeutic concentration of DPH, added before, during, or after hypoxia, decreased this release of glutamate. These results suggest that DPH may protect against glutamate-mediated neurotoxicity associated with stroke.

引用

页码：127 / 130

页数：4

共 12 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS
BENVENISTE, H
DREJER, J
SCHOUSBOE, A
DIEMER, NH
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) : 1369 - 1374
[2] EFFECTS OF ANOXIA ON THE STIMULATED RELEASE OF AMINO-ACID NEUROTRANSMITTERS IN THE CEREBELLUM INVITRO
BOSLEY, TM
WOODHAMS, PL
GORDON, RD
BALAZS, R
[J]. JOURNAL OF NEUROCHEMISTRY, 1983, 40 (01) : 189 - 201
[3] THE EFFECTS OF CONVULSANT AND ANTI-CONVULSANT DRUGS ON THE RELEASE OF RADIOLABELED GABA, GLUTAMATE, NORADRENALINE, SEROTONIN AND ACETYLCHOLINE FROM RAT CORTICAL SLICES
DEBOER, T
STOOF, JC
VANDUIJN, H
[J]. BRAIN RESEARCH, 1982, 253 (1-2) : 153 - 160
[4] EFFECT OF ISCHEMIA ON THE INVIVO RELEASE OF STRIATAL DOPAMINE, GLUTAMATE, AND GAMMA-AMINOBUTYRIC ACID STUDIED BY INTRACEREBRAL MICRODIALYSIS
GLOBUS, MYT
BUSTO, R
DIETRICH, WD
MARTINEZ, E
VALDES, I
GINSBERG, MD
[J]. JOURNAL OF NEUROCHEMISTRY, 1988, 51 (05) : 1455 - 1464
[5] ISCHEMIA-INDUCED SHIFT OF INHIBITORY AND EXCITATORY AMINO-ACIDS FROM INTRACELLULAR TO EXTRACELLULAR COMPARTMENTS
HAGBERG, H
LEHMANN, A
SANDBERG, M
NYSTROM, B
JACOBSON, I
HAMBERGER, A
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1985, 5 (03) : 413 - 419
[6] CA-2+-DEPENDENT AND CA-2+- INDEPENDENT GLUTAMATE RELEASE, ENERGY STATUS AND CYTOSOLIC FREE CA-2+ CONCENTRATION IN ISOLATED NERVE-TERMINALS FOLLOWING METABOLIC INHIBITION - POSSIBLE RELEVANCE TO HYPOGLYCEMIA AND ANOXIA
KAUPPINEN, RA
MCMAHON, HT
NICHOLLS, DG
[J]. NEUROSCIENCE, 1988, 27 (01) : 175 - 182
[7] CRITERIA FOR THE IDENTIFICATION OF CENTRAL NEUROTRANSMITTERS, AND THEIR APPLICATION TO STUDIES WITH SOME NERVE-TISSUE PREPARATIONS INVITRO
ORREGO, F
[J]. NEUROSCIENCE, 1979, 4 (08) : 1037 - 1057
[8] TEMPORAL PROFILE OF NEURONAL DAMAGE IN A MODEL OF TRANSIENT FOREBRAIN ISCHEMIA
PULSINELLI, WA
BRIERLEY, JB
PLUM, F
[J]. ANNALS OF NEUROLOGY, 1982, 11 (05) : 491 - 498
[9] K+ EFFLUX PATHWAYS AND NEUROTRANSMITTER RELEASE ASSOCIATED TO HIPPOCAMPAL ISCHEMIA - EFFECTS OF GLUCOSE AND OF K+ CHANNEL BLOCKERS
SCHAEFFER, P
LAZDUNSKI, M
[J]. BRAIN RESEARCH, 1991, 539 (01) : 155 - 158
[10] BLOCKADE OF N-METHYL-D-ASPARTATE RECEPTORS MAY PROTECT AGAINST ISCHEMIC DAMAGE IN THE BRAIN
SIMON, RP
SWAN, JH
GRIFFITHS, T
MELDRUM, BS
[J]. SCIENCE, 1984, 226 (4676) : 850 - 852

← 1 2 →