COMPARATIVE ACTIVITIES OF PIPERACILLIN AND TAZOBACTAM AGAINST CLINICAL ISOLATES OF LEGIONELLA SPP

We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an approximately 10-fold higher inoculum, the following results were obtained, expressed as MICs for 50 and 90% of strains tested (MIC range): piperacillin, 4 and 16 (0.25 to 32) mug/ml; tazobactam, 0.5 and 1 (0.125 to 2) mug/ml; and piperacillin-tazobactam (expressed in terms of MIC of piperacillin) 0.5 and 1 (0.03 to 2) mug/ml. Tazobactam alone and the combination with piperacillin were more active than piperacillin alone at the higher inoculum.