EFFECT OF ENCAPSULATION ON THE ANTIINFLAMMATORY PROPERTIES OF SUPEROXIDE-DISMUTASE AFTER ORAL-ADMINISTRATION

被引：21

作者：

REGNAULT, C

ROCHARVEILLER, M

TISSOT, M

SARFATI, G

GIROUD, JP

POSTAIRE, E

HAZEBROUCQ, G

机构：

[1] HOP COCHIN, SERV PHARMACOL, CNRS, URA 1534, F-75674 PARIS, FRANCE

[2] HOP COCHIN, SERV BIOCHIM A, F-75674 PARIS, FRANCE

[3] HOP PARIS, PHARM CENT, SERV SCI, PARIS, FRANCE

来源：

CLINICA CHIMICA ACTA | 1995年 / 240卷 / 02期

关键词：

SUPEROXIDE DISMUTASE; LIPOSOMES; CERAMIDES; ANTIINFLAMMATORY PROPERTIES; BIOAVAILABILITY;

D O I：

10.1016/0009-8981(95)06133-X

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Anti-inflammatory properties of free superoxide dismutase and superoxide dismutase encapsulated into liposomes, with or without ceramides, have been investigated. Two models were investigated: carrageenan paw oedema and pleurisy. Animals were fed by repeated doses, twice daily from day 1 until day 4. Evaluation consisted of measurement of paw oedema volume with determination of prostaglandin E-2, thromboxane B-2 and 6-keto-prostaglandin F-1 alpha levels. Polymorphonuclear oxidative metabolism was evaluated by measurement of superoxide anion production, Levels of superoxide dismutase were determined in cells and pleural exudates. Higher anti-inflammatory effects were obtained after eight administrations of encapsulated forms (0.5 mg/kg) whereas free superoxide dismutase have shown no effects. Ceramides enhanced the results obtained.

引用

页码：117 / 127

页数：11

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