SERTRALINE 50 MG DAILY - THE OPTIMAL DOSE IN THE TREATMENT OF DEPRESSION

被引:83
作者
PRESKORN, SH [1 ]
LANE, RM [1 ]
机构
[1] PFIZER INT PHARMACEUT GRP,NEW YORK,NY 10017
关键词
COMPLIANCE; CYTOCHROME P4502D6; DOSE PROPORTIONAL; DOSE-RESPONSE; DRUG INTERACTION; FLEXIBLE TITRATION; FORCED TITRATION; SERTRALINE;
D O I
10.1097/00004850-199510030-00001
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The dose regimen for sertraline in the treatment of depression has been well established. The starting dose, 50 mg/day, is the usually effective therapeutic dose, and the optimal dose when considering both efficacy and tolerability for most patients, For patients who do not show an adequate therapeutic response within 2-4 weeks, the dose of sertraline can be increased in 50 mg/day increments at no less than weekly intervals to a maximum of 200 mg/day, Sertraline is generally given as a single daily dose and may be administered at any time of the day. In contrast to other selective serotonin reuptake inhibitors, there is no need for altered dose recommendations in the elderly.
引用
收藏
页码:129 / 141
页数:13
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