INHIBITION OF ADHERENCE OF GIARDIA-INTESTINALIS BY HUMAN NEUTROPHILS AND MONOCYTES

被引：17

作者：

CROUCH, AA ^{[1
]}

SEOW, WK ^{[1
]}

WHITMAN, LM ^{[1
]}

SMITH, SE ^{[1
]}

THONG, YH ^{[1
]}

机构：

[1] UNIV QUEENSLAND,MATER CHILDRENS HOSP,DEPT CHILD HLTH,IMMUNOBIOL RES LAB,BRISBANE 4101,AUSTRALIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1991年 / 85卷 / 03期

关键词：

D O I：

10.1016/0035-9203(91)90297-C

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Human neutrophils and monocytes were found to be capable of interfering with the in vitro adherence of Giardia intestinalis. Significantly greater inhibition of adherence was shown by stimulated phagocytic cells than by unstimulated cells. Both azurophil and specific granules extracted from the cytoplasm of neutrophils were equally potent in their adherence inhibitory activity. Dose-dependent effects on adherence were observed with granular enzymes and reactive oxygen species. Lower concentrations of reactive oxygen species were required for adherence inhibition that for growth inhibition. These results suggest that the adherence mechanism of G. intestinalis may be a feasible target for immunological attack by phagocytic cells.

引用

页码：375 / 379

页数：5

共 42 条

[1]

AGGARWAL A, 1986, J IMMUNOL, V136, P3486

[2] EXCRETION OF LIPOTEICHOIC ACID BY GROUP-A-STREPTOCOCCI - INFLUENCE OF PENICILLIN ON EXCRETION AND LOSS OF ABILITY TO ADHERE TO HUMAN ORAL MUCOSAL CELLS [J].

ALKAN, ML ;

BEACHEY, EH .

JOURNAL OF CLINICAL INVESTIGATION, 1978, 61 (03) :671-677

[3] PROTECTION AGAINST INFECTION WITH GIARDIA-MURIS BY MILK CONTAINING ANTIBODY TO GIARDIA [J].

ANDREWS, JS ;

HEWLETT, EL .

JOURNAL OF INFECTIOUS DISEASES, 1981, 143 (02) :242-246

[4] GIARDIA-LAMBLIA - AXENIC GROWTH IN AUTOCLAVED AND FILTERED DIAMONDS TYI-S-33 MEDIUM [J].

BELOSEVIC, M ;

FAUBERT, GM ;

CROLL, NA ;

MACLEAN, JD .

CANADIAN JOURNAL OF ZOOLOGY-REVUE CANADIENNE DE ZOOLOGIE, 1982, 60 (07) :1673-1675

[5]

BELOSEVIC M, 1986, CLIN EXP IMMUNOL, V65, P622

[6]

BOREHAM PFL, 1981, AUST PAEDIATR J, V17, P209

[7] SUBCELLULAR-LOCALIZATION OF THE B-CYTOCHROME COMPONENT OF THE HUMAN NEUTROPHIL MICROBICIDAL OXIDASE - TRANSLOCATION DURING ACTIVATION [J].

BORREGAARD, N ;

HEIPLE, JM ;

SIMONS, ER ;

CLARK, RA .

JOURNAL OF CELL BIOLOGY, 1983, 97 (01) :52-61

[8]

BRANDBOR.LL, 1967, GASTROENTEROLOGY, V52, P143

[9] INSOLUBLE IMMUNE-COMPLEXES AND CHRONIC PERIODONTAL-DISEASES IN MAN AND DOG [J].

CLAGETT, JA ;

PAGE, RC .

ARCHIVES OF ORAL BIOLOGY, 1978, 23 (03) :153-165

[10] EFFECT OF 23 CHEMOTHERAPEUTIC-AGENTS ON THE ADHERENCE AND GROWTH OF GIARDIA-LAMBLIA INVITRO [J].

CROUCH, AA ;

SEOW, WK ;

THONG, YH .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1986, 80 (06) :893-896

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