FLUORINATED AMINO-ACIDS .3. SYNTHESIS OF BETA-DIFLUOROMETHYL-M-TYROSINE

被引：6

作者：

SABOL, JS ^{[1
]}

BRAKE, NW ^{[1
]}

MCDONALD, IA ^{[1
]}

机构：

[1] SIBIA, LA JOLLA, CA 92037 USA

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)73169-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The difluoromethyl carboxylic acid S-(+)-9 was synthesized to assign the absolute configuration of diastereomers 2a and 2b, and the completion of the synthesis of beta-difluoromethyl-m-tyrosines 1a,b is reported.

引用

页码：1821 / 1824

页数：4

共 9 条

[1]

COREY EJ, 1972, TETRAHEDRON LETT, P3769

[2] A NEW STEREOSPECIFIC SYNTHESIS OF TRISUBSTITUTED OLEFINS . STEREOSPECIFIC SYNTHESIS OF FARNESOL [J].

COREY, EJ ;

KATZENEL.JA ;

POSNER, GH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1967, 89 (16) :4245-&

[3] ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETIC ACID, A VERSATILE REAGENT FOR DETERMINATION OF ENANTIOMERIC COMPOSITION OF ALCOHOLS AND AMINES [J].

DALE, JA ;

DULL, DL ;

MOSHER, HS .

JOURNAL OF ORGANIC CHEMISTRY, 1969, 34 (09) :2543-&

[4] THE ASYMMETRIC-SYNTHESIS OF ALPHA-AMINO-ACIDS - ELECTROPHILIC AZIDATION OF CHIRAL IMIDE ENOLATES, A PRACTICAL APPROACH TO THE SYNTHESIS OF (R)-ALPHA-AZIDO AND (S)-ALPHA-AZIDO CARBOXYLIC-ACIDS [J].

EVANS, DA ;

BRITTON, TC ;

ELLMAN, JA ;

DOROW, RL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (10) :4011-4030

[5]

Hill R. K., 1984, ASYMMETRIC SYNTHESIS, V3, P503

[6]

Hudlicky M., 1988, ORG REACTIONS, V35, P513, DOI DOI 10.1002/0471264180.0R035.03

[7]

MIDLAND MM, 1984, ORG SYNTH, V63, P57

[8]

SABOL JS, 1994, TETRAHEDRON LETT 2, V35

[9]

SIBI MP, 1993, ORG PREP P INT, V63, P57

← 1 →