WHOLE-BLOOD SEROTONIN DURING CLOMIPRAMINE TREATMENT OF JUVENILE OBSESSIVE-COMPULSIVE DISORDER

被引：13

作者：

HANNA, GL ^{[1
]}

YUWILER, A ^{[1
]}

CANTWELL, DP ^{[1
]}

机构：

[1] UNIV MICHIGAN,MED CTR,DEPT PSYCHIAT,ANN ARBOR,MI 48109

来源：

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1089/cap.1993.3.223

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Whole-blood serotonin (5-HT) concentration was assessed in 15 children and adolescents with obsessive-compulsive disorder (OCD) before and during treatment with clomipramine (CMI). Pretreatment blood 5-HT content had no correlation with clinical improvement during drug therapy. CMI administration produced a marked reduction in blood 5-HT content during the first 4 weeks of treatment, but not during the second 4 weeks of treatment. Significant clinical improvement occurred, however, during both 4-week periods of treatment. The percentage of change in blood 5-HT concentrations during the first 4 weeks of CMI administration had a significant positive correlation with the percentage of clinical change reached after 8 weeks of treatment. In contrast, CMI dosage was negatively correlated with the declines in symptom severity and blood 5-HT content. The results provide further evidence that the inhibition of 5-HT uptake by CMI is associated with its amelioration of OCD. The temporal delay between 5-HT uptake inhibition and clinical improvement suggests that biochemical adaptations to the pharmacological actions of CMI, rather than the direct drug effects themselves, are associated with clinical improvement.

引用

页码：223 / 229

页数：7

共 28 条

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